The Senate rejected a key proposal repealing and replacing ObamaCare on Tuesday night, as senators start a days-long debate on healthcare.

Senators voted 43-57 on a procedural hurdle for the measure that included the GOP repeal and a replace bill, the Better Care Reconciliation Act, as well as proposals from GOP Sens. Ted Cruz (Texas) and Rob Portman (Ohio).

GOP Sens. Susan Collins (Maine), Bob Corker (Tenn.), Tom Cotton (Ark.), Lindsey Graham (S.C.), Dean Heller (Nev.), Mike Lee (Utah), Jerry Moran (Kan.), Lisa Murkowski (Alaska) and Rand Paul (Ky.) voted against the repeal-replace proposal on the procedural hurdle. No Democrats voted for it.

The proposal was the first amendment to get a vote after senators took up the House-passed healthcare bill, which is being used as a vehicle for any Senate action, earlier Tuesday.

But it was widely expected to fail because it needed 60 votes because the Congressional Budget Office (CBO) didn’t analyze either the Cruz or Portman proposal that was packaged in with BCRA.

Tuesday night’s vote doesn’t prevent GOP leadership from offering another repeal and replace amendment, or another version of BCRA.

It could also help GOP leadership get rank-and-file senators on the record, as they try to figure out a path forward.

A vote on an amendment that would repeal much of ObamaCare is expected on Wednesday.

Cruz acknowledged ahead of the late night vote that the amendment wasn’t likely to be approved, but appeared optimistic that Republicans would be able to get to an agreement before a final vote this week.

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